Discussion 2: The Dopamine Hypothesis
Dopamine is implicated in addiction, and is often the direct or indirect target of substance abuse treatments. Using what youâ€ve learned this week, and in prior weeks, about dopamine and its importance in regulating mood and behavior, focus on the neurotransmitterâ€s role in addiction.
Post by Day 4 an analysis of the role that dopamine plays in addiction. Craft a cohesive analysis of how the dopamine system is involved in drug craving. How is it that addictive drugs co-opt brain systems to drive use and abuse? Provide specific evidence from peer-reviewed literature to support your position.
Respond by Day 6 to at least one of your colleagues†postings, and compare and contrast your interpretations.
Readings
Advokat, C. D., & Comaty, J. E., & Julien, R. M. (2019). Julien’s primer of drug action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs (14th ed.). New York, NY: Worth Publishers/Macmillan.
Chapter 4, “Epidemiology and Neurobiology of Addiction†(pp. 106-128)
Lichtblau, L. (2011). Psychopharmacology demystified (1st ed.). Clifton Park, NY: Delmar/Cengage Learning.
Chapter 7, “Neurobiology of Addiction†(pp. 87–105)
Hancock, S. D, & McKim, W. A. (2018). Drugs and behavior: An introduction to behavioral pharmacology (8th ed.). Upper Saddle River, NJ: Pearson.
Chapter 5, “Substance Use and Addictive Disorders†(pp. 85-117)
Ali, S. F., Onaivi, E. S., Dodd, P. R., Cadet, J. L., Schenk, S., Kuhar, M. J., & Koob, G. F. (2011). Understanding the global problem of drug addiction is a challenge for IDARS scientists. Current Neuropharmacology, 9(1), 2–7.Understanding the Global Problem of Drug Addiction is a Challenge for IDARS Scientists by Ali, S.F.; Onaivi, E.S.; Dodd, P.R.; Cadet, J.L.; Schenk, S.; Kuhar, M.J.; Koob, G.F., in Current Neuropharmacology, Vol. 9/Issue 1. Copyright 2011 by Bentham Science Publishers Ltd. Reprinted by permission of Bentham Science Publishers Ltd. via the Copyright Clearance Center.
Edwards, S. & Koob, G. F. (2010). Neurobiology of dysregulated motivational systems in drug addiction. Future Neurology, 5(3), 393–401.Retrieved from the Walden Library databases.
Koob, G., & Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 35(1), 217–238.Retrieved from the Walden Library databases.
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